Identifying neural activity in neural stem cell organoides

Thursday, May 18, 2017 - 5:30pm

Pluripotent stem cells can be created from tissue samples taken from a patient. These stem cells can then be converted into neural tissue through application of appropriate cellular signals. When this neural tissue is grown in a flask, it makes little chunks of neural tissue that may have similar properties as the patient's own brain tissue. In this project, you will be taking these neural organoids and trying different neural recording methods to identify if they produce activity similar to that seen in the brain. If these orgnoids do produce neural acitivity, you will then try to identify differences in the neural activity can be observed in organoids generated from control patients from patients with epilepsy.